Yes, it is possible. The only thing which does not quite work
in Mathematica 6 is the integration of the documentation notebooks
into the so-called "Documentation Center", i.e., the on-line
Help system of Mathematica.
-- In fact: I wrote most of FeynCalc on Unix/Linux/NextStep during the 90-ies. With the (still) unbeatable development environment, the editor "vi" ... There is no need to use a "FrontEnd", i.e., notebooks. They just come in handy for typesetting and organizing work.
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